Synthesis, Characterization and Antimicrobial Activity of Cu(II) And Zn(II) Metal Complexes from 2-[(2-Hydroxyphenyl)Imino]Methyl Phenol

Muhammad M., Aliyu H. N., Usman B., Aisha A. A., Mahmoud A. A., Hassan U. F.

Abstract


The Schiff base was synthesized by refluxing equimolar amount of 2-aminophenol and Salicyaldehyde. It was subsequently reacted with metal(II) salts to form the corresponding metal(II) complexes. The compounds were characterized by solubility test, melting point and decomposition temperature, magnetic susceptibility, Atomic absorption spectrophotometry (A.A.S), FTIR analysis, molar conductance. The compounds were observed to be soluble in Dimethylsulfoxide (DMSO), Dimethylformamide (DMF), insoluble in water, methanol, ethyl ether, n-hexane, ethyl acetate, petroleum, ether, but slightly soluble in acetone, ethanol and chloroform. The melting point and decomposition temperature of the Schiff base and its metal(II) complexes were found to be within the range of 69.5-263 oC.The magnetic moment value of Cu complex is 1.82 BM but Zn complex is diamagnetic . The elemental analyses of the complexes were observed using A.A.S and the metal to ligand ratio was established to be 1:1. Molar conductivity analyses indicated that the ligand acts as neutral and tridentate coordinated through azomethine nitrogen atom to the central metal ion and the oxygen atoms of the phenolic group. Molar conductance values of the metal(II) complexes were found to be in the range of 11.69-13.07 Ω-1cm2 mol-1.The ligand and its metal(II) complexes were also screened for antibacterial and antifungal activities against three bacteria isolates (Staphylococcus aureus, Eschirichia coli, and Salmonella typhi) and three fungi isolates (Aspergillus flarus, Mucor iudicus, and Aspergillus niger) by disc diffusion method respectively, and the result indicated that the complexes were more active than the free ligand.


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Abdullahi.O.S and Gareth M.W, (2013). Antimicrobial Activity and Cu(II) complexes of Schiff base derived from ortho-aminophenol and Salicyaldehyde derivatives. Journal of Chemical and Pharmaceutical Research, 5(10):147-154.

Aurora Reiss, Stelian Florea, Theodor C Aproiu, and Nicolae Stanica (2009). Synthesis, Characterization, and Antibacterial Activity of some transition metals with the Schiff base N-(2-furanymethylene)-3-amino dibenzofuran. Turkey Journal of Chemistry 33 (2009), 775-783.

Cleiton M. S, Daniel. L. S, Luzia. V. M, Rosemeire. B. A, Maria. A.R, Cleide. V. B, and Angelo Fatima (2010). Schiff bases: A short review of their Antimicrobial Activity. Journal of advanced Research 2, 1-8.

Elena.P, Valeriu. F, Aurelian. G, Donald.P, and Victor. T, (2013). Synthesis, and Characterization of some new Cu(II), Ni(II), and Zn(II) complexes with Salicyaldehyde thiosemicarbazones antibacterial, antifungal and in vitro antileukemia activity. Journal of molecules 18, 8812-8836.

Gurbuz. D, Cinarli. A, Tavman. A, and Tan. S. B. A, (2013). Synthesis, Characterization, and Antimicrobial Activity of some transition metal complexes of N-(5-chloro-2-hydroxylphenyl)-3-methoxy salicyaldehyde. Bull. Chemical Society Ethiophia 29(1), 63-74.

Hassan. R. H. A, Gamal. A. S, Samila. A. H, and Ahmed. I. H, (2013). Preparation, Characterization of some metal complexes of glipizide. Der Pharma Chemica, 5(6):156-163.

Khan. S. A, Asiri. A.M, Kumar. S, and Sharma. K (2014). Greensynthesis, Antimicrobial Activity and computational study of pyrazolinepyrimidine derivatives from 3(3, 4-dimethoxyphenyl-1-(2, 5-dimethylthiophen-3-yl)propanone. European Journal of Chemistry vol. 5, pp. 85-90.

Katarzyna. B, and Elzbieta. L. C, (2014). Schiff bases has interesting range of applications in various fields of Science. CHEMIK 2014, 68, 2, 129-134.

Kriza, A, Ababel.L.V, Cioatera. N, Rau. I, and Stanica. N, (2010).Synthesis and Structural Studies of complexes of Cu, Co, Ni, and Zn with Isonicotinic acid hydrazide and Isonicotinic acid (1-naphthylmethylene)hydrazide. Journal of the Serbian Chemical Society 75(2)229-242.

Mounica. K, Anupama. B, Pragathi.J, and Gyanakumeri. C, (2010). Synthesis, Characterization, and Biological Activity of a Schiff base derived from 3-methoxysalicyaldehyde and 2-aminobenzoic acid and its transition metal complexes. Journal of Science Research. 2(3), 513-524.

Prasad. A. V. G. S, Rao. P. V, and Prasad. S. S, (2014). Novel Synthesis, Characterization, and Antimicrobial Screening of Schiff base complex. International Journal of Pharmacy, 4(4)215-218.

Sauza. P, Garcia-vazquez. J. A, Masaguer. J. R: Transition Metal Chemistry; 10(1985)410.

Sherifat. M. Wakil, Oluwatoon. B. A. Agbaje, and Aderoju .A. Osowole (2014). Synthesis, Spectroscopic, Characterization and Antimicrobial Activities of some mixed Drug metal (II) complexes of sulfamethoxazole and paracetamol.

Uddin.M. N, Salam. M. A, Chowdhury. D. A, Sultana. J, and Halim. M. E, (2014).Triginal Pyramidal Pb(II) complexes of Schiff bases of Orthoaminophenol: Synthesis, Characterization, and Antibacterial Evaluation. International Journal of Advanced Research in Chemical Science volume 1, pp 47-56.

Vogel, (1972). Quantitative inorganic analysis including elementary instrumental analysis 3rd edition, Lodon Lowe and Brydone printer pp 493-537.

Xavier. A, and Srividhya. N (2014). Synthesis, and Study of Schiff base Ligands. Journal of Applied Chemistry. Volume 7, Pp 06-15.


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